Inhibitors of Deubiquitinating Enzymes Interfere with the SARS-CoV-2 Papain-like Protease and Block Virus Replication In Vitro

The ubiquitin proteasome system (UPS), particularly its deubiquitinating enzymes (DUBs), play a key role in the replication cycle of coronaviruses.The SARS-CoV-2 papain-like protease (Plpro) is known to process the viral polyproteins to form the replicase transcriptase complex and to counteract the host viral response.Recently, it was shown that th

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Genital self-mutilation in a case of first episode psychosis

Genital self-mutilation (GSM) is a much Sexual Health rare finding and more commonly associated with psychosis when it comes to comparison with self-mutilation as a whole.There have been anecdotal case reports of GSM in psychotic disorders with most of them being in long standing psychoses.We describe herein a case of GSM during treadbelt the first

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